Premium
Thermoresponsive DNA by Intercalation of dsDNA with Oligoethylene‐Glycol‐Functionalized Small‐Molecule Intercalators
Author(s) -
Bera Debaditya,
Verdonck Lars,
Glassner Mathias,
Madder Annemieke,
Hoogenboom Richard
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800900
Subject(s) - intercalation (chemistry) , ethylene glycol , thermoresponsive polymers in chromatography , polymer , small molecule , molecule , dna , chemistry , materials science , chemical engineering , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry , phase (matter) , reversed phase chromatography , engineering
Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene‐glycol‐modified proflavine intercalators. The thermoresponsiveness of the dsDNA‐intercalator complex originates from the heating‐induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small‐molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.