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Self‐Healing Polymeric Hydrogel Formed by Metal–Ligand Coordination Assembly: Design, Fabrication, and Biomedical Applications
Author(s) -
Shi Liyang,
Ding Pinghui,
Wang Yuzhi,
Zhang Yu,
Ossipov Dmitri,
Hilborn Jöns
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800837
Subject(s) - self healing hydrogels , terpyridine , chelation , ligand (biochemistry) , bipyridine , metal ions in aqueous solution , nanotechnology , coordination complex , materials science , self assembly , covalent bond , combinatorial chemistry , metal , chemistry , polymer chemistry , organic chemistry , biochemistry , receptor , crystal structure
Self‐healing hydrogels based on metal–ligand coordination chemistry provide new and exciting properties that improve injectability, rheological behaviors, and even biological functionalities. The inherent reversibility of coordination bonds improves on the covalent cross‐linking employed previously, allowing for the preparation of completely self‐healing hydrogels. In this article, recent advances in the development of this class of hydrogels are summarized and their applications in biology and medicine are discussed. Various chelating ligands such as bisphosphonate, catechol, histidine, thiolate, carboxylate, pyridines (including bipyridine and terpyridine), and iminodiacetate conjugated onto polymeric backbones, as well as the chelated metal ions and metal ions containing inorganic particles, which are used to form dynamic networks, are highlighted. This article provides general ideas and methods for the design of self‐healing hydrogel biomaterials based on coordination chemistry.