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Bacteria‐Targeted Supramolecular Photosensitizer Delivery Vehicles for Photodynamic Ablation Against Biofilms
Author(s) -
Gao Yifan,
Wang Jing,
Hu Dengfeng,
Deng Yongyan,
Chen Tingting,
Jin Qiao,
Ji Jian
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800763
Subject(s) - photosensitizer , photodynamic therapy , biofilm , antimicrobial , chemistry , micelle , polyethylene glycol , cytotoxicity , supramolecular chemistry , pseudomonas aeruginosa , bacteria , microbiology and biotechnology , combinatorial chemistry , biophysics , photochemistry , biochemistry , organic chemistry , in vitro , biology , aqueous solution , crystal structure , genetics
Photodynamic therapy (PDT) is believed to be a potent method for biofilm treatments. However, undesired damage to normal cells may be caused due to the nonselective nature of PDT. Therefore, targeted PDT is preferred on one hand to enhance antimicrobial effects and on the other hand to reduce cytotoxicity to normal cells. For this purpose, novel bacteria‐targeted photosensitizer delivery micelles are fabricated, taking advantage of α‐cyclodextrin (α‐CD)/polyethylene glycol (PEG) supramolecular assembly. Hydrophilic antimicrobial peptide (AMP) Magainin I is covalently bound with PEG, working as a bacterial targeting group as well as the stabilizing shell of the supramolecular micelles. Photosensitizer Chlorin e6 (Ce6) is grafted onto α‐CD. The micelles exhibit excellent bacterial targeting effects. Compared to α‐CD‐Ce6, the supramolecular micelles possess enhanced biofilm killing ability against Gram (−) Pseudomonas aeruginosa biofilms and Gram (+) methicillin‐resistant Staphylococcus aureus (MRSA) biofilms while reducing cytotoxicity to NIH/3T3 model cells.