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Oxidation‐Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues
Author(s) -
ElMohtadi Farah,
d'Arcy Richard,
Tirelli Nicola
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800699
Subject(s) - reactive oxygen species , nanotechnology , drug discovery , catechol , chemistry , computer science , biochemical engineering , materials science , biochemistry , engineering
In this review, a general introduction to biological oxidants (focusing on reactive oxygen species, ROS) and the biomedical rationale behind the development of materials capable of responding to ROS is provided. The state of the art for preparative aspects and mechanistic responses of the most commonly used macromolecular ROS‐responsive systems, including polysulfides, polyselenides, polythioketals, polyoxalates, and also oligoproline‐ and catechol‐based materials, is subsequently given. The endowment of multiple responsiveness, with specific emphasis on the cases where a molecular logic gate behavior can be obtained, is focused on. Finally, fundamental open issues, which include implications of the “drug”‐like character of ROS‐responsive materials (inherent anti‐inflammatory behavior) and the poor quantitative understanding of ROS roles in biology, are discussed.