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Synthesis of Functional Polymer Particles from Morita–Baylis–Hillman Polymerization
Author(s) -
Ramakers Gijs,
D'Incal Claudio,
Gagliardi Mick,
Molin Daniël G. M.,
Junkers Tanja
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800678
Subject(s) - biocompatibility , polymer , polymerization , materials science , functional polymers , biodegradation , lactic acid , nanotechnology , combinatorial chemistry , chemistry , chemical engineering , organic chemistry , composite material , biology , bacteria , engineering , genetics
Functional synthetic polymers are frequently explored for their use in the biomedical field. To fulfill the stringent demands of biodegradability and compatibility, the materials need to be versatile and tunable. Post‐modification is often considered challenging for well‐known degradable materials like poly(lactic acid) because of their chemical inertness. In this work a procedure is proposed to produce densely functionalized polymer particles using oligomeric precursors synthesized via the Morita–Baylis–Hillman reaction. This allows for a variety of post‐modification reactions to serve bio‐conjugation or tuning of the material properties. The particles are subjected to basic media and found to be degradable. Furthermore, cytotoxicity tests confirm good biocompatibility. Finally, as a proof of concept to demonstrate the versatility of the particles, post‐modification reactions are carried out through the formation of imines.