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Nano‐Sized Lipidated Dendrimers as Potent and Broad‐Spectrum Antibacterial Agents
Author(s) -
Gide Mussie,
Nimmagadda Alekhya,
Su Ma,
Wang Minghui,
Teng Peng,
Li Chunpu,
Gao Ruixuan,
Xu Hai,
Li Qi,
Cai Jianfeng
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800622
Subject(s) - dendrimer , antimicrobial , amphiphile , rational design , nanotechnology , chemistry , antibacterial activity , bacteria , combinatorial chemistry , nanomaterials , polymer , materials science , biochemistry , biology , organic chemistry , copolymer , genetics
There is considerable interest in the development of antimicrobial polymers including dendrimers due to the ease of synthesis and low manufacturing cost compared to host defense peptides (HDPs). Herein, a new class of nanomaterials—lipidated amphiphilic dendrimers—is presented that mimic the antibacterial mechanism of HDPs by compromising bacterial cell membranes. Unlike conventional dendrimers that are prepared generation by generation symmetrically with molecular weight distribution, these lipidated dendrimers are prepared on the solid phase with a hanging lipid tail and precisely controlled structure. It is shown through rational design that these lipidated dendrimers display potent and selective antimicrobial activity against both Gram‐positive and Gram‐negative bacteria, including multidrug‐resistant strains. In addition to antibacterial activity against planktonic bacteria, these dendrimers are also shown to inhibit bacterial biofilms effectively. This class of dendrimers as a new class of biomaterials may lead to a useful generation of antibiotic agents with practical applications.