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Combinatorial Synthesis of Peptoid Arrays via Laser‐Based Stacking of Multiple Polymer Nanolayers
Author(s) -
Mattes Daniela. S.,
Streit Bettina,
Bhandari Dhaka R.,
Greifenstein Juliane,
Foertsch Tobias C.,
Münch Stephan W.,
Ridder Barbara,
v. BojničićKninski Clemens,
NesterovMueller Alexander,
Spengler Bernhard,
Schepers Ute,
Bräse Stefan,
Loeffler Felix F.,
Breitling Frank
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800533
Subject(s) - peptoid , materials science , monomer , stacking , polymer , laser , molecule , matrix (chemical analysis) , mass spectrometry , nanotechnology , chemical engineering , polymer chemistry , organic chemistry , chemistry , optics , chromatography , peptide , composite material , biochemistry , physics , engineering
Here, the combinatorial synthesis of molecule arrays via a laser‐assisted process is reported. Laser‐transferred polymer nanolayers with embedded monomers, activators, or bases can be reliably stacked on top of each other, spot‐by‐spot, to synthesize molecule arrays. These various chemicals in the nanometer‐thin layers are mixed by heat or solvent vapor, inducing coupling reactions. As an example, peptoid arrays with a density of 10 000 spots per cm 2 with the sub‐monomer or monomer method are generated. Moreover, successful reactions spot‐by‐spot are verified by laser‐transferring MALDI‐matrix (Matrix‐assisted laser desorption/ionization) followed by MALDI mass spectrometry imaging.