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Enzyme‐Responsive Polymer Nanoparticles via Ring‐Opening Metathesis Polymerization‐Induced Self‐Assembly
Author(s) -
Wright Daniel B.,
Thompson Matthew P.,
Touve Mollie A.,
Carlini Andrea S.,
Gianneschi Nathan C.
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800467
Subject(s) - thermolysin , polymerization , polymer , nanoparticle , self assembly , metathesis , materials science , polymer chemistry , chemical engineering , ring opening metathesis polymerisation , romp , nanoreactor , ring opening polymerization , chemistry , nanotechnology , organic chemistry , enzyme , engineering , trypsin
Open‐to‐air aqueous‐phase ring‐opening metathesis polymerization‐induced self‐assembly (ROMPISA) is reported for forming well‐defined peptide polymer nanoparticles at room temperature and with high solids concentrations (10 w/w%). For these materials, ROMPISA is shown to provide control over molecular weight with high conversion while open‐to‐air. Moreover, these peptide polymer nanoparticles can spontaneously rearrange into larger aggregate scaffolds in the presence of the proteolytic enzyme, thermolysin. This work demonstrates the robust nature of ROMPISA, highlighted here for the preparation of stimuli‐responsive nanostructures in one pot, in air.