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Secondary Structure‐Driven Hydrogelation Using Foldable Telechelic Polymer–Peptide Conjugates
Author(s) -
Otter Ronja,
Henke Nina Alexandra,
Berac Christian,
Bauer Tobias,
Barz Matthias,
Seiffert Sebastian,
Besenius Pol
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800459
Subject(s) - peptide , self assembly , amphiphile , pentapeptide repeat , folding (dsp implementation) , nanofiber , polymer , dipeptide , supramolecular chemistry , conjugate , copolymer , polymer chemistry , materials science , supramolecular polymers , peptide synthesis , chemistry , nanotechnology , organic chemistry , molecule , biochemistry , mathematical analysis , mathematics , engineering , electrical engineering
The synthesis of ABA and ABA′ triblock polyethylene glycol‐and polysarcosine‐peptide conjugates is reported. The A/A′ peptides are based on phenylalanine(F)‐histidine(H) pentapeptide sequences FHFHF, which promote pH‐switchable β‐sheet self‐assembly into nanorods in water. Only parallel β‐sheet‐driven folding and intermolecular assembly using ABA triblock polymer–peptide conjugates leads to interstrand cross‐linking and hydrogelation, highlighting the impact of supramolecular interactions‐directed structure formation at the nano‐ and mesoscopic level.