Premium
Injectable Enzymatically Cross‐linked Hydrogels with Light‐Controlled Degradation Profile
Author(s) -
Cheng Yilong,
He Chaoliang,
Ren Kaixuan,
Rong Yan,
Xiao Chunsheng,
Ding Jianxun,
Zhuang Xiuli,
Chen Xuesi
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800272
Subject(s) - self healing hydrogels , horseradish peroxidase , ethylene glycol , peg ratio , hydrogen peroxide , chemistry , degradation (telecommunications) , polymer chemistry , materials science , chemical engineering , organic chemistry , enzyme , telecommunications , finance , computer science , economics , engineering
An advanced hydrogel that features facile formation and injectability as well as light‐controlled degradation profile is reported here. By modifying 4‐arm poly(ethylene glycol) (4‐arm PEG) with 2‐nitrobenzyl (NB) and phenol, the 4‐arm PEG precursor solutions could form enzymatically cross‐linked hydrogels in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H 2 O 2 ). The gelation time, mechanical strength, and porous structure could be simply tuned by the concentration of HRP and H 2 O 2 . Moreover, the hydrogels underwent controlled degradation under UV light irradiation via photo‐cleavage reaction of the NB ester bond. The hydrogels exhibited negligible cytotoxicity toward mouse fibroblast L929 cells in vitro and can be manipulated through injection in vivo.