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MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers
Author(s) -
Jin Manyu,
Zhang Yanqun,
Gao Ge,
Xi Qiaoyue,
Yang Yun,
Yan Luomei,
Zhou Hua,
Zhao Yongxia,
Wu Cunqi,
Wang Lidan,
Lei Yongqian,
Yang Wei,
Xu Jingwei
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800258
Subject(s) - dendrimer , gadolinium , conjugated system , in vivo , macromolecule , polyelectrolyte , chemistry , magnetic resonance imaging , polymerization , carboxylate , mri contrast agent , polymer , combinatorial chemistry , materials science , nuclear magnetic resonance , polymer chemistry , stereochemistry , organic chemistry , biochemistry , medicine , radiology , microbiology and biotechnology , biology , physics
Three complexes of gadolinium‐based on dentritic molecules are reported as magnetic resonance imaging (MRI) contrast agents. Their ligands feature four carboxylate groups, which contribute to good water solubility and a strong combination with metal ions. As a new attempt, coupling polymerization is carried out to make a combination of conjugated polyelectrolytes and dendrimers for MRI contrast agents. For comparison, mononuclear and binuclear complexes are also reported. The investigation suggests that the contrast agent with the newly designed macromolecular skeleton provides higher longitudinal relaxivity value (36.2 m m −1 s −1 ) and more visible enhancement in in vivo and in vitro MR images than the small molecular ones. In addition, extremely low cytotoxicity and main clearance via hepatobiliary are confirmed, which reduces the deterioration of chronic kidney disease. All the results indicate that these three complexes are generally applicable as promising clinical contrast agents.