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Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications
Author(s) -
Liu Minghuan,
Teng Choon Peng,
Win Khin Yin,
Chen Yisong,
Zhang Xiaoyan,
Yang DaPeng,
Li Zibiao,
Ye Enyi
Publication year - 2019
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800216
Subject(s) - curcumin , plga , biocompatibility , antimicrobial , nanotechnology , solubility , chemistry , ingredient , nanoparticle , curcuma , fluorescence , materials science , traditional medicine , organic chemistry , food science , biochemistry , physics , quantum mechanics , medicine
As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been upon the investigation of pharmaceutical activities of curcumin, yet the fluorescence of curcumin is a bit far from well‐studied. The major drawbacks associated with curcumin are its poor aqueous solubility and low stability. In this communication, the encapsulation of fluorescent turmeric extract into polymeric nanoparticles (NPs) for bioimaging and antibacterial applications is reported. Through poly( d , l ‐lactic‐co‐glycolic acid) (PLGA) encapsulation, solubility of curcumin is greatly increased, and the biodegradable nature of PLGA further enhances the biocompatibility of curcumin. These Cur‐PLGA NPs are successfully demonstrated to be efficient fluorescence probes for bioimaging, and promising for antibacterial application.