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Intramolecular Copper‐Containing Hyperbranched Polytriazole Assemblies for Label‐Free Cellular Bioimaging and Redox‐Triggered Copper Complex Delivery
Author(s) -
Ban Qingfu,
Du Junjie,
Sun Wen,
Chen Jianxin,
Wu Si,
Kong Jie
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201800171
Subject(s) - amphiphile , copper , intramolecular force , cycloaddition , click chemistry , triazole , combinatorial chemistry , chemistry , drug delivery , polymer chemistry , nanotechnology , materials science , catalysis , organic chemistry , copolymer , polymer
Intramolecular Cu‐containing amphiphilic hyperbranched polytriazoles are purposefully designed and synthesized via a Cu(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) reaction, and are self‐assembled into spherical assemblies. Based on the metal coordination ability of triazole groups, the copper catalyst can be intramolecularly coordinated with triazole groups in the CuAAC, producing the copper‐triazole coordination polyprodrugs. Unexpectedly, the amphiphilic hyperbranched polytriaozle assemblies can also be applied as fluorescent nanoprobes with aggregation‐induced emission enhancement. The cellular uptake verifies their functional application for cellular bioimaging. Furthermore, the results of cell viability indicate that the mPEG‐ hb ‐S‐S‐PTAs assemblies are effective copper delivery systems for cancer therapy by releasing the anticancer copper‐triazole coordination complexes. Therefore, the amphiphilic hyperbranched polytriazoles may have very promising applications in complex copper delivery and label‐free cellular bioimaging.