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Macroscopic Adhesion of Thermoreversible ABC Triblock Copolymer‐Based Hydrogels Via Boronic Acid–Sugar Complexation
Author(s) -
Tamate Ryota,
Takahashi Kotomi,
Ueki Takeshi,
Akimoto Aya Mizutani,
Yoshida Ryo
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201700835
Subject(s) - copolymer , phenylboronic acid , self healing hydrogels , polymer chemistry , boronic acid , chain transfer , polymerization , raft , adhesion , chemistry , materials science , radical polymerization , organic chemistry , polymer , catalysis
Two complementary thermoreversible ABC triblock copolymers containing either phenylboronic acids with low p K a values or galactosyl groups in the hydrophilic B blocks are synthesized by sequential reversible addition‐fragmentation chain transfer polymerization and subsequent modification of the functional groups. Both ABC triblock copolymers undergo reversible sol‐to‐gel transitions upon temperature change and form physically cross‐linked hydrogels under physiological conditions. Furthermore, the spontaneous adhesion of these thermoreversible hydrogels via the formation of boronic esters between the phenylboronic acid and galactosyl groups under physiological conditions is realized for the first time.