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Polypeptide Polymer Brushes by Light‐Induced Surface Polymerization of Amino Acid N ‐Carboxyanhydrides
Author(s) -
Stukenkemper Timo,
Paquez Xavier,
Verhoeven M. W. G. M.,
Hensen Emiel J. M.,
Dias Aylvin A.,
Brougham Dermot F.,
Heise Andreas
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201700743
Subject(s) - polymer chemistry , polymerization , contact angle , surface modification , polymer , grafting , x ray photoelectron spectroscopy , materials science , polyester , amide , chemistry , chemical engineering , organic chemistry , composite material , engineering
Silicon wafers are decorated with photoamine generator 4,5‐dimethoxy‐2‐nitrobenzyl 3‐(triethoxysilyl)propyl carbamate. UV‐irradiation in the presence of benzyl‐ l ‐glutamate N ‐carboxyanhydride is carried out, resulting in the release of the surface‐bound primary amines, making them viable N ‐carboxyanhydride (NCA) polymerization initiators. Successful polypeptide grafting is confirmed by water contact angle measurements as well as by ellipsometry, revealing a poly(benzyl‐ l ‐glutamate) (PBLG) layer of ≈3 nm. X‐ray photoelectron spectroscopy confirms the presence of amide groups in the grafted PBLG while time‐of‐flight secondary ion mass spectroscopy provides additional evidence for the presence of PBLG on the surface. Evaluation of negative control samples confirms successful UV surface grafting. The approach is thus established as a viable general method for light exposure directable polypeptide functionalization of silicon surfaces.