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Fabrication of pH‐ and Thermoresponsive Three‐Layered Micelles via Host–Guest Interactions
Author(s) -
Zhang Jingyan,
Zhou Haiou,
Liu Hao,
Hu Jinming,
Liu Shiyong
Publication year - 2018
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201700225
Subject(s) - methacrylate , ethylene glycol , micelle , polymer chemistry , cyclodextrin , copolymer , atom transfer radical polymerization , methyl methacrylate , ether , aqueous solution , materials science , chemistry , organic chemistry , polymer
Well‐defined β‐cyclodextrin (β‐CD)‐terminated double hydrophilic diblock copolymers (DHBCs), β‐CD‐ poly(di(ethylene glycol) methyl ether methacrylate) (PMEO 2 MA)‐ b ‐poly(2‐(diethylamino)ethyl methacrylate) (PDEA) ( BP1 ) and β‐CD‐PDEA‐ b ‐PMEO 2 MA ( BP2 ), are synthesized via sequential atom transfer radical polymerizations of di(ethylene glycol) methyl ether methacrylate and 2‐(diethylamino)ethyl methacrylate using alkynyl‐functionalized initiator, followed by click reactions with an excess of mono‐azido‐substituted β‐cyclodextrin (β‐CD‐N 3 ). The micellization behavior of these as‐prepared DHBCs in aqueous solutions suffers from insufficient colloidal stabilities at basic pH and high temperatures (e.g., pH 9 and 45 °C), resulting in the formation of macroscopic precipitations. However, the stabilities of colloidal nanoparticles can be remarkably enhanced as a result of the convenient formation of three‐layered micelles by taking advantage of host–guest interactions of BP1 / BP2 and Ad‐terminated poly(ethylene glycol). The pH‐ and thermoresponsive three‐layered micelles with enhanced stability may augur promising applications in targeted drug delivery and controlled intelligent release.