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Accelerated Combinatorial High Throughput Star Polymer Synthesis via a Rapid One‐Pot Sequential Aqueous RAFT (rosa‐RAFT) Polymerization Scheme
Author(s) -
Cosson Steffen,
Danial Maarten,
SaintAmans Julien Rosselgong,
CooperWhite Justin J.
Publication year - 2017
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600780
Subject(s) - raft , reversible addition−fragmentation chain transfer polymerization , copolymer , polymerization , chain transfer , polymer , materials science , acrylate , aqueous solution , monomer , computer science , chemistry , combinatorial chemistry , polymer chemistry , nanotechnology , chemical engineering , radical polymerization , organic chemistry , engineering
Advanced polymerization methodologies, such as reversible addition‐fragmentation transfer (RAFT), allow unprecedented control over star polymer composition, topology, and functionality. However, using RAFT to produce high throughput (HTP) combinatorial star polymer libraries remains, to date, impracticable due to several technical limitations. Herein, the methodology “rapid one‐pot sequential aqueous RAFT” or “rosa‐RAFT,” in which well‐defined homo‐, copolymer, and mikto‐arm star polymers can be prepared in very low to medium reaction volumes (50 µL to 2 mL) via an “arm‐first” approach in air within minutes, is reported. Due to the high conversion of a variety of acrylamide/acrylate monomers achieved during each successive short reaction step (each taking 3 min), the requirement for intermediary purification is avoided, drastically facilitating and accelerating the star synthesis process. The presented methodology enables RAFT to be applied to HTP polymeric bio/nanomaterials discovery pipelines, in which hundreds of complex polymeric formulations can be rapidly produced, screened, and scaled up for assessment in a wide range of applications.