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Recent Progress in the Design of Monodisperse, Sequence‐Defined Macromolecules
Author(s) -
Solleder Susanne C.,
Schneider Rebekka V.,
Wetzel Katharina S.,
Boukis Andreas C.,
Meier Michael A. R.
Publication year - 2017
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600711
Subject(s) - macromolecule , dispersity , sequence (biology) , oligomer , polymer , monomer , context (archaeology) , materials science , conjugated system , phase (matter) , polymer science , chemistry , nanotechnology , combinatorial chemistry , polymer chemistry , organic chemistry , paleontology , biochemistry , biology
This review describes different synthetic strategies towards sequence‐defined, monodisperse macromolecules, which are built up by iterative approaches and lead to linear non‐natural polymer structures. The review is divided in three parts: solution phase‐, solid phase‐, and fluorous‐ and polymer‐tethered approaches. Moreover, synthesis procedures leading to conjugated and non‐conjugated macromolecules are considered and discussed in the respective sections. A major focus in the evaluation is the applicability of the different approaches in polymer chemistry. In this context, simple procedures for monomer and oligomer synthesis, overall yields, scalability, purity of the oligomers, and the achievable level of control (side‐chains, backbone, stereochemistry) are important benchmarks.