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Amphiphilic Imbalance and Stabilization of Block Copolymer Micelles on‐Demand through Combinational Photo‐Cleavage and Photo‐Crosslinking
Author(s) -
Zhang Xuan,
Wang Youpeng,
Li Guo,
Liu Zhaotie,
Liu Zhongwen,
Jiang Jinqiang
Publication year - 2017
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600543
Subject(s) - micelle , copolymer , dynamic light scattering , phthalimide , amphiphile , ethylene oxide , materials science , photochemistry , polymer chemistry , merocyanine , photodissociation , polymer , chemistry , organic chemistry , photochromism , nanoparticle , nanotechnology , aqueous solution , composite material
An amphiphilic block copolymer of poly(ethylene oxide)‐ b ‐poly(( N ‐methacryloxy phthalimide)‐ co ‐(7‐(4‐vinyl‐benzyloxyl)‐4‐methylcoumarin)) (PEO 45 ‐ b ‐P(MAPI 36 ‐ co ‐VBC 4 )) is designed to improve the micellar stability during the photo‐triggered release of hydrophobic cargoes. Analysis of absorption and emission spectra, solution transmittance, dynamic light scattering, and transmission electron microscopy supports that polymer micelles of PEO 45 ‐ b ‐P(MAPI 36 ‐ co ‐VBC 4 ) upon the combinational irradiation of 365 and 254 nm light can be solubilized through the photolysis of phthalimide esters and simultaneously crosslinked via the partially reversible photo‐dimerization of coumarins. The photo‐triggered release experiment shows that the leakage of doxorubicin molecules from crosslinked micelles can be predictably regulated by controlling the irradiation time of 365 and 254 nm light.