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Exploiting Bisphosphonate–Bioactive‐Glass Interactions for the Development of Self‐Healing and Bioactive Composite Hydrogels
Author(s) -
Diba Mani,
An Jie,
Schmidt Stephan,
Hembury Mathew,
Ossipov Dmitri,
Boccaccini Aldo R.,
Leeuwenburgh Sander C. G.
Publication year - 2016
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600353
Subject(s) - self healing hydrogels , bioactive glass , simulated body fluid , composite number , materials science , self healing , polymer , bisphosphonate , tissue engineering , mineralization (soil science) , biomedical engineering , chemical engineering , nanotechnology , chemistry , composite material , osteoporosis , polymer chemistry , organic chemistry , scanning electron microscope , medicine , alternative medicine , engineering , pathology , endocrinology , nitrogen
Hydrogels are widely recognized as promising candidates for various biomedical applications, such as tissue engineering. Recently, extensive research efforts have been devoted to the improvement of the biological and mechanical performance of hydrogel systems by incorporation of functional groups and/or inorganic particles in their composition. Bisphosphonates are a class of drugs, commonly used for treatment of osteoporosis, which exhibit a strong binding affinity for hydroxyapatite. In this study, the binding affinity of a bisphosphonate‐functionalized polymer, hyaluronan, toward a bioactive glass (i.e., 45S5 Bioglass) is evaluated using force–distance measurements with atomic force microscopy. The strong interaction between bisphosphonate and bioactive glass is then exploited to develop organic–inorganic composite hydrogels and the viscoelastic and self‐healing ability of these materials are investigated. Finally, the stability and mineralization behavior of these hydrogels are evaluated in simulated body fluid. Following this approach, injectable, bioactive and self‐healing organic–inorganic composite hydrogels are produced, which mineralize abundantly and rapidly in simulated body fluid. These properties render these composite gels suitable for applications in bone‐tissue engineering.