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Polymer‐Chlorambucil Drug Conjugates: A Dynamic Platform of Anticancer Drug Delivery
Author(s) -
Saha Biswajit,
Haldar Ujjal,
De Priyadarsi
Publication year - 2016
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600146
Subject(s) - chlorambucil , copolymer , dynamic light scattering , chain transfer , materials science , methacrylate , drug delivery , polymerization , polymer chemistry , conjugate , polymer , polyethylene glycol , chemistry , conjugated system , combinatorial chemistry , radical polymerization , organic chemistry , nanoparticle , nanotechnology , medicine , mathematical analysis , surgery , mathematics , chemotherapy , cyclophosphamide
Recently, polymer drug conjugates (PDCs) have attracted considerable attention in the treatment of cancer. In this work, a simple strategy has been developed to make PDCs of an antitumor alkylating agent, chlorambucil, using a biocompatible disulphide linker. Chlorambucil‐based chain transfer agent was used to prepare various homopolymers and block copolymers in a controlled fashion via reversible addition–fragmentation chain transfer polymerization. Chlorambucil conjugated block copolymer, poly(polyethylene glycol monomethyl ether methacrylate)‐ b ‐poly(methyl methacrylate), formed nanoaggregates in aqueous solutions, which are characterized by dynamic light scattering and field emission‐scanning electron microscopy. Finally, the simplicity of the design is exemplified by performing a release study of chlorambucil under reducing condition by using D,L‐dithiothreitol.
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