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UV‐Responsive Supramolecular Vesicles with Double Hydrophobic Chains
Author(s) -
Zhang Xiaojin,
Dai Yu,
Chen Xin,
Zhuo Renxi
Publication year - 2016
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201600077
Subject(s) - vesicle , supramolecular chemistry , doxorubicin hydrochloride , chemistry , cyclodextrin , supramolecular assembly , drug delivery , polymer chemistry , organic chemistry , membrane , doxorubicin , biochemistry , molecule , biology , chemotherapy , genetics
In order to improve the stability of polymeric vesicles, supramolecular vesicles are developed via self‐assembly of the inclusion of γ ‐cyclodextrin ( γ ‐CD) and 1‐pyrenemethyl palmitate (Py‐pal). The inclusion has one hydrophilic head and double hydrophobic tails, which looks like the phospholipid. From the transmission electron microscopy (TEM) image, it can be observed that the average diameter of supramolecular vesicles is approximately 55 nm and there is a huge cavity in supramolecular vesicles. Due to the photo‐breakable ester of Py‐pal, supramolecular vesicles are broken under UV irradiation. Supramolecular vesicles are used as UV‐responsive drug carriers to release the hydrophilic drug such as doxorubicin hydrochloride (DOX•HCl).