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Nitrile Oxide‐Norbornene Cycloaddition as a Bioorthogonal Crosslinking Reaction for the Preparation of Hydrogels
Author(s) -
Truong Vinh X.,
Zhou Kun,
Simon George P.,
Forsythe John S.
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201500314
Subject(s) - self healing hydrogels , bioorthogonal chemistry , nitrile , norbornene , ethylene glycol , cycloaddition , ethylene oxide , polymer , click chemistry , polymer chemistry , materials science , oxide , chemical engineering , chemistry , organic chemistry , polymerization , copolymer , catalysis , engineering
This communication describes the first application of cycloaddition between an in situ generated nitrile oxide with norbornene leading to a polymer crosslinking reaction for the preparation of poly(ethylene glycol) hydrogels under physiological conditions. Hydrogels with high water content and robust physical strength are readily formed within 2–5 min by a simple two‐solution mixing method which allows 3D encapsulation of neuronal cells. This bioorthogonal crosslinking reaction provides a simple yet highly effective method for preparation of hydrogels to be used in bioengineering.