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Efficient Synthesis of Single‐Chain Globules Mimicking the Morphology and Polymerase Activity of Metalloenzymes
Author(s) -
SanchezSanchez Ana,
Arbe Arantxa,
Kohlbrecher Joachim,
Colmenero Juan,
Pomposo José A.
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201500252
Subject(s) - self healing hydrogels , single chain , thermal stability , polymer , chemistry , hydrolysis , enzyme , copper , nanotechnology , combinatorial chemistry , chemical engineering , materials science , polymer chemistry , biochemistry , organic chemistry , biology , antibody , engineering , immunology
Endowing unimolecular soft nanoobjects with biomimetic functions is attracting significant interest in the emerging field of single‐chain technology. Inspired by the compartmentalized structure and polymerase activity of metalloenzymes, copper‐containing compact nanoglobules have been designed, synthesized, and characterized endowed with metalloenzyme mimicking characteristics toward controlled synthesis of water‐soluble polymers and thermoresponsive hydrogels. When compared to metalloenzymes, artificial nanoobjects endowed with metalloenzyme mimicking characteristics offer increased stability against thermal changes and reduced degradability by hydrolytic enzymes.