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Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery
Author(s) -
Sardon Haritz,
Tan Jeremy P. K.,
Chan Julian M. W.,
Mantione Daniele,
Mecerreyes David,
Hedrick James L.,
Yang Yi Yan
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201500247
Subject(s) - lower critical solution temperature , ethylene glycol , isophorone diisocyanate , aqueous solution , drug delivery , materials science , polymer chemistry , diol , cloud point , chemistry , chemical engineering , polyurethane , organic chemistry , nanotechnology , polymer , copolymer , engineering
A new class of thermoresponsive random polyurethanes is successfully synthesized and characterized. Poly(ethylene glycol) diol ( M n = 1500 Da) and 2,2‐dimethylolpropionic acid are reacted with isophorone diisocyanate in the presence of methane sulfonic acid catalyst. It is found that these polyurethanes are thermoresponsive in aqueous media and manifest a lower critical solution temperature (LCST) that can be easily tuned from 30 °C to 70 °C by increasing the poly(ethylene glycol) content. Their sharp LCST transitions make these random polyurethanes ideal candidates for stimuli‐responsive drug delivery applications. To that end, the ability of these systems to efficiently sequester doxorubicin (up to 36 wt%) by means of a sonication/dialysis method is successfully demonstrated. Additionally, it is also demonstrated that accelerated doxorubicin release kinetics from the nanoparticles can be attained above the LCST.