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Long‐Lived Phosphorescent Iridium(III) Complexes Conjugated with Cationic Polyfluorenes for Heparin Sensing and Cellular Imaging
Author(s) -
Jiang Jiayang,
Zhang Chuanqi,
Lin Wenpeng,
Liu Yahong,
Liu Shujuan,
Xu Yunjian,
Zhao Qiang,
Huang Wei
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201400654
Subject(s) - phosphorescence , conjugated system , cationic polymerization , polyelectrolyte , polymer , iridium , materials science , fluorescence , luminescence , photochemistry , polyfluorene , biosensor , nanotechnology , chemistry , polymer chemistry , optoelectronics , organic chemistry , catalysis , physics , quantum mechanics , composite material
The applications of conjugated polyelectrolytes in biosensing and bioimaging have attracted more and more research interests due to their excellent photophysical properties. In this work, a new series of conjugated polyelectrolytes containing long‐lived phosphorescent Ir(III) complexes is designed and synthesized, which can be used for ratiometric and lifetime‐based sensing of heparin utilizing the electrostatic interaction between cationic polymers and anionic heparin. By changing the ligand structures of Ir(III) complexes, the sensing performances of phosphorescent‐conjugated polyelectrolytes (PCPEs) are optimized. In addition, the application of PCPEs in cellular imaging is carried out. These polymers can be applied for specific staining of cell membrane. Importantly, utilizing the long emission lifetime of phosphorescent signal of Ir(III) complexes, time‐gated luminescent imaging is carried out, which can eliminate the short‐lived background fluorescence interferences from the environment or biological samples.