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Biodegradable Micelles Capable of Mannose‐Mediated Targeted Drug Delivery to Cancer Cells
Author(s) -
Yin Lichen,
Chen Yongbing,
Zhang Zhonghai,
Yin Qian,
Zheng Nan,
Cheng Jianjun
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201400650
Subject(s) - micelle , mannose , drug delivery , targeted drug delivery , amphiphile , moiety , chemistry , polyester , biocompatible material , combinatorial chemistry , doxorubicin , materials science , biophysics , nanotechnology , biochemistry , organic chemistry , polymer , copolymer , biomedical engineering , chemotherapy , medicine , biology , aqueous solution , surgery
A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac‐OCA)‐ b ‐(poly(Tyr(alkynyl)‐OCA)‐ g ‐mannose) (PLA‐ b ‐(PTA‐ g ‐mannose), that is synthesized via controlled ring‐opening polymerization of O ‐carboxyanhydride (OCA) and highly efficient “Click” chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively encapsulated into the micelles, and the mannose moiety allows active targeting of the micelles to cancer cells that specifically express mannose receptors, which thereafter enhances the anticancer efficiency of the drug. Comprised entirely of biodegradable and biocompatible polyesters, this micellar system demonstrates promising potentials for targeted drug delivery and cancer therapy.