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Hydrogen Bonding in Aprotic Solvents, a New Strategy for Gelation of Bioinspired Catecholic Copolymers with N ‐Isopropylamide
Author(s) -
VatankhahVarnoosfaderani Mohammad,
GhavamiNejad Amin,
Hashmi Saud,
Stadler Florian J.
Publication year - 2015
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201400501
Subject(s) - copolymer , hydrogen bond , methacrylate , polymer chemistry , materials science , reactivity (psychology) , supramolecular chemistry , kinetics , chemical engineering , drug delivery , polymer , chemistry , organic chemistry , nanotechnology , molecule , composite material , medicine , alternative medicine , physics , engineering , pathology , quantum mechanics
Copolymers of N ‐isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self‐healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV–vis and 1 H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self‐healing properties are tested rheologically. The produced reversible organogel can self‐encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual‐targeted and controlled drug delivery and release—by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.