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Macromol. Rapid Commun. 19/2013
Author(s) -
Huang Jin,
Zhang Qiang,
Li GuangZhao,
Haddleton David M.,
Wallis Russell,
Mitchell Daniel,
Heise Andreas,
Becer C. Remzi
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201370063
Subject(s) - dc sign , surface plasmon resonance , glycan , chemistry , drug delivery , nanotechnology , chemical biology , polymer science , lectin , biophysics , glycoprotein , materials science , biochemistry , nanoparticle , biology , dendritic cell , genetics , antigen
Front Cover: Synthetic glycopolymers and their interactions with lectins have attracted great attention not only in synthetic polymer chemistry but also in chemical biology. Natural glycans exhibit a GlycoCode that runs many biological processes in our body. Creating synthetic mimics of these compounds and understanding the GlycoCode is crucial in immunology, biomaterials, and drug delivery applications. Herein, the binding properties of glycopolypeptides and dendritic cell lectin, DC‐SIGN, are investigated using surface plasmon resonance. These structures are found to effectively inhibit the binding between HIV glycoprotein, gp120, and DC‐SIGN. Further details can be found in the article by Huang, Q. Zhang, G.‐Z. Li, D. M. Haddleton, R. Wallis, D. Mitchell, A. Heise,* and C. R. Becer* on page 1542.