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Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers
Author(s) -
Sokolovskaya Ekaterina,
Barner Leonie,
Bräse Stefan,
Lahann Jörg
Publication year - 2014
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300909
Subject(s) - ethylene glycol , polymer , hydrazide , self healing hydrogels , peg ratio , polymer chemistry , aldehyde , materials science , chemistry , chemical engineering , organic chemistry , catalysis , finance , engineering , economics
The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)‐based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on‐demand fabrication of hydrogels. For rapid gelation, a hydrazide‐functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG‐based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds.