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Stimuli‐Triggered Growth and Removal of a Bioreducible Nanoshell on Nanoparticles
Author(s) -
Han LiFen,
Chen QianBao,
Hu ZongTao,
Piao JiaGang,
Hong ChunYan,
Yan JunJie,
You YeZi
Publication year - 2014
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300885
Subject(s) - nanoshell , nanoparticle , polymer , dithiothreitol , materials science , pegylation , nanotechnology , peg ratio , chemical engineering , chemistry , organic chemistry , polyethylene glycol , composite material , finance , engineering , economics , enzyme
A new and easy method of stimuli‐triggered growth and removal of a bioreducible nanoshell on nanoparticles is reported. The results show that pH or temperature could induce the aggregation of disulfide‐contained branched polymers at the surface of nanoparticles; subsequently, the aggregated polymers could undergo intermolecular disulfide exchange to cross‐link the aggregated polymers, forming a bioreducible polymer shell around nanoparticles. When these nanoparticles with a polymer shell are treated with glutathione (GSH) or d,l ‐dithiothreitol (DTT), the polymer shell could be easily removed from the nanoparticles. The potential application of this method is demonstrated by easily growing and removing a bioreducible shell from liposomes, and improvement of in vivo gene transfection activity of liposomes with a bioreducible PEG shell.