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Triazole‐Containing Hydrogels for Time‐Dependent Sustained Drug Release
Author(s) -
Mishra Vivek,
Jung SeoHyun,
Park Jong Mok,
Jeong Han Mo,
Lee Hyungil
Publication year - 2014
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300585
Subject(s) - self healing hydrogels , swelling , methacrylate , triazole , click chemistry , monomer , drug , chemistry , drug delivery , materials science , controlled release , combinatorial chemistry , polymer chemistry , nanotechnology , organic chemistry , pharmacology , polymer , composite material , medicine
The purpose of this study is to develop novel triazole‐containing hydrogels (TGs) as drug carrier and to investigate the sustained drug release accomplished by their time‐dependent swelling behavior. The synthetic pathway of TGs includes: (1) DCC‐coupling on hydroxyethyl methacrylate (HEMA) to prepare HEMA‐alkyne (HA), (2) click‐coupling to prepare a triazole‐ring‐containing monomer (TM), and (3) the synthesis of a series of TGs. The aggregation between triazole rings is found to be responsible for drug release controllability. Rhodamine 6G is studied as a model anticancer drug for release experiments. The effects of pH and temperature on the properties of sustained drug release are also studied.