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Design, Synthesis, and Application of Stimulus‐Sensing Biohybrid Hydrogels
Author(s) -
Hotz Natascha,
Wilcke Louisa,
Weber Wilfried
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300468
Subject(s) - self healing hydrogels , nanotechnology , drug delivery , polymer , computer science , allosteric regulation , biochemical engineering , materials science , chemistry , engineering , organic chemistry , polymer chemistry , enzyme , composite material
A key feature of any living system is the ability to sense and react to the environmental stimuli. The biochemical characterization of the underlying biological sensors combined with advances in polymer chemistry has enabled the development of stimulus‐sensitive biohybrid materials that translate most diverse chemical and biological input into a precise change in material properties. In this review article, we first describe synthesis strategies of how biological and chemical polymers can functionally be interconnected. We then provide a comprehensive overview of how the different properties of biological sensor molecules such as competitive target binding and allosteric modulation can be harnessed to develop responsive materials with applications in tissue engineering and drug delivery.