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Chemical Control of Yeast Cell Division by Cross‐Linked Shells of Catechol‐Grafted Polyelectrolyte Multilayers
Author(s) -
Lee Juno,
Yang Sung Ho,
Hong SeokPyo,
Hong Daewha,
Lee Haeshin,
Lee HeeYoon,
Kim YangGyun,
Choi Insung S.
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300444
Subject(s) - polyelectrolyte , catechol , cell division , nanotechnology , yeast , division (mathematics) , chemistry , hyaluronic acid , cell , biophysics , materials science , chemical engineering , biochemistry , polymer , organic chemistry , biology , engineering , arithmetic , mathematics , genetics
The chemical control of cell division has attracted much attention in the areas of single cell‐based biology and high‐throughput screening platforms. A mussel‐inspired cytocompatible encapsulation method for achieving a “cell‐division control” with cross‐linked layer‐by‐layer (LbL) shells is developed. Catechol‐grafted polyethyleneimine and hyaluronic acid are chosen as polyelectrolytes for the LbL process, and the cross‐linking of polyelectrolytes is performed at pH 8.5. Cell division is controlled by the number of the LbL nanolayers and cross‐linking reaction. We also suggest a new measuring unit, t − 2.0OD 600 , for quantifying “cell‐division timing” based on microbial growth kinetics.