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Temperature and pH‐Tunable Fluorescence Nanoplatform with Graphene Oxide and BODIPY‐Conjugated Polymer for Cell Imaging and Therapy
Author(s) -
Mosaiab Tamim,
In Insik,
Park Sung Y.
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300413
Subject(s) - bodipy , fluorescence , conjugated system , graphene , fluorescence lifetime imaging microscopy , confocal microscopy , nanoparticle , biophysics , nanotechnology , fluorescence microscope , cancer cell , materials science , polymer , oxide , drug delivery , confocal , chemistry , cancer , organic chemistry , medicine , physics , geometry , mathematics , quantum mechanics , microbiology and biotechnology , biology
This paper demonstrates the development of pH and thermo‐responsive fluorescent nanoparticles, which are composed of graphene oxide (GO) with BODIPY conjugated PEG, to trigger the detection of cancer cells through imaging based on intracellular accommodation. Responsiveness to pH is studied using atomic force microscopy and apparent thickness differences are seen with changes in pH. Confocal images of the nanoparticles (NPs) exhibit remarkably bright fluorescence at lysosomal pH, while no fluorescence is observed under a physiological environment, making the NPs a novel fluorescent probe. The NPs are able to accumulate the hydrophobic anticancer drug DOX due to the hydrophobic surface of GO and show excellent drug release behavior. Therefore, the NPs developed are novel candidates for a fluorescent probe to identify cancer cells and a drug carrier for cancer therapy.