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Polypeptoids by Living Ring‐Opening Polymerization of N‐Substituted N‐Carboxyanhydrides from Solid Supports
Author(s) -
Gangloff Niklas,
Fetsch Corinna,
Luxenhofer Robert
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201300269
Subject(s) - polymerization , monomer , living polymerization , polymer chemistry , radical polymerization , chemistry , precipitation polymerization , chain growth polymerization , bulk polymerization , living anionic polymerization , cationic polymerization , nucleophile , ring opening polymerization , polymer , organic chemistry , catalysis
The nucleophilic living ring‐opening polymerization of N‐substituted glycine N‐carboxyanhydrides using solid‐phase synthesis resins is reported. By variation of experimental parameters, products with near Poisson distributions are obtained. As opposed to reversible deactivation radical polymerization, the living polymerization is demonstrated to be viable to high monomer conversion and through multiple monomer addition steps. Successful preparation of a multiblock copolypeptoid is proof for a highly living and robust character of the solid‐phase peptoid polymerization.