Premium
Radiolabeled Nanogels for Nuclear Molecular Imaging
Author(s) -
Singh Smriti,
Bingöl Bahar,
Morgenroth Agnieszka,
Mottaghy Felix M.,
Möller Martin,
Schmaljohann Jörn
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200744
Subject(s) - nanogel , internalization , amphiphile , chemistry , chelation , in vivo , aqueous solution , molecular imaging , materials science , aqueous medium , nanotechnology , biophysics , drug delivery , organic chemistry , biochemistry , cell , polymer , copolymer , microbiology and biotechnology , biology
An efficient and simple synthesis approach to form stable 68 Ga‐labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self‐assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well‐defined spherical shape with a diameter of 290 ± 50 nm. The radionuclide 68 Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these 68 Ga‐nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.