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Star‐Shaped Polymer Consisting of a Porphyrin Core and Poly( L ‐lysine) Dendron Arms: Synthesis, Drug Delivery, and In Vitro Chemo/Photodynamic Therapy
Author(s) -
Ma Dong,
Liu ZongHua,
Zheng QianQian,
Zhou XiaoYan,
Zhang Yi,
Shi YunFeng,
Lin JianTao,
Xue Wei
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200742
Subject(s) - dendrimer , phototoxicity , porphyrin , chemistry , gel permeation chromatography , cytotoxicity , micelle , photodynamic therapy , click chemistry , drug delivery , polymer chemistry , drug carrier , doxorubicin , amphiphile , chitosan , nuclear chemistry , combinatorial chemistry , materials science , polymer , aqueous solution , organic chemistry , in vitro , copolymer , biochemistry , chemotherapy , medicine , surgery
A novel star‐shaped polymer, porphyrin‐poly(L‐lysine) dendrons (PP‐PLLD), is synthesized by the click reaction between azido‐modified porphyrin and propargyl focal point poly(L‐lysine) dendrons. Its chemical structure is characterized by 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP‐PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μg mg −1 . By in vitro toxicity assay, PP‐PLLD has no dark cytotoxicity but has significant phototoxicity. Moreover, DOX‐loaded PP‐PLLD shows a higher cytotoxicity under the light condition than PP‐PLLD or DOX alone, suggesting PP‐PLLD has a potential application in combined photodynamic therapy and chemotherapy.