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Photo‐Degradable, Protein–Polyelectrolyte Complex‐Coated, Mesoporous Silica Nanoparticles for Controlled Co‐Release of Protein and Model Drugs
Author(s) -
Wan Xuejuan,
Liu Tao,
Hu Jinming,
Liu Shiyong
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200673
Subject(s) - polyelectrolyte , methacrylate , copolymer , ethylene glycol , nanoparticle , mesoporous silica , polymer chemistry , chemistry , monomer , rhodamine b , bovine serum albumin , chemical engineering , mesoporous material , materials science , polymer , organic chemistry , nanotechnology , chromatography , catalysis , photocatalysis , engineering
The fabrication of photo‐degradable, protein–polyelectrolyte complex (PPC)‐coated, mesoporous silica nanoparticles (MSNs) and their controlled co‐release of protein and model drugs is reported. Random copolymers composed of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), and a photolabile o ‐nitrobenzyl‐containing monomer, 5‐(2′‐(dimethylamino)ethoxy)‐2‐nitrobenzyl methacrylate (DENBMA), are first anchored onto the MSNs and then quaternary aminated, to obtain positively charged P(OEGMA‐ co ‐TENBMA) which exhibits photo‐induced charge conversion characteristics. PPCs consisting of P(OEGMA‐ co ‐TENBMA) and the protein bovine serum albumin (BSA) are utilized as capping agents for the nanopores of the MSNs. Upon UV irradiation, charge conversion of P(OEGMA‐ co ‐TENBMA) can lead to the disruption of PPCs on MSNs and co‐release of BSA and rhodamine B by electrostatic repulsion.