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Smart Poly( N ‐isopropylacrylamide) Containing Iridium(III) Complexes as Water‐Soluble Phosphorescent Probe for Sensing and Bioimaging of Homocysteine and Cysteine
Author(s) -
Liu Shujuan,
Qiao Weili,
Cao Guoyi,
Chen Yang,
Ma Yun,
Huang Yanqin,
Liu Xiangmei,
Xu Wenjuan,
Zhao Qiang,
Huang Wei
Publication year - 2013
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200589
Subject(s) - phosphorescence , photoluminescence , iridium , aqueous solution , cysteine , chemistry , combinatorial chemistry , fluorescence , materials science , polymer chemistry , nanotechnology , photochemistry , organic chemistry , optoelectronics , physics , quantum mechanics , enzyme , catalysis
Homocysteine (Hcy) and cysteine (Cys) are two important kinds of amino acids in human bodies. Herein, we synthesized an iridium(III) complex‐functionalized poly( N ‐isopropylacrylamide) and its hydrogel, which could be used as the excellent phosphorescent bioprobe for sensing Hcy and Cys. Their detection can be realized in aqueous system through the variations in absorption and photoluminescence spectra. Furthermore, living cell imaging experiments demonstrate that the phosphorescent bioprobe is membrane permeable and can monitor the changes of Hcy and Cys within living cells. In addition, the probe is also thermoresponsive, and its photoluminescence intensified with increasing temperature. These results suggests that this bioprobe has promising application in biomedical fields.