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Shell Cross‐linking of Cyclodextrin‐Based Micelles via Supramolecular Chemistry for the Delivery of Drugs
Author(s) -
Yhaya Firdaus,
Binauld Sandra,
Kim Yoseop,
Stenzel Martina H.
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200473
Subject(s) - copolymer , micelle , polymer chemistry , chain transfer , lower critical solution temperature , raft , cyclodextrin , acrylate , chemistry , adamantane , polymerization , reversible addition−fragmentation chain transfer polymerization , materials science , radical polymerization , polymer , aqueous solution , organic chemistry
A block copolymer based on poly( N ‐isopropyl acrylamide) (PNIPAAm) and a block with a statistical distribution of poly(2‐hydroxyethyl acrylate) (PHEA) and repeating unit with carrying β ‐cyclodextrin was prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization and click reaction. Addition of poly(2‐hydroxyethyl acrylate‐ s ‐adamantylmethyl acrylate) P(HEA 17 ‐ s ‐AdMA 7 ) above the LCST of the block copolymer led to capture of the micelle structure of 36 nm against disassembly. The drug‐ (albendazole) loaded supramolecular assembly, which was fixed via host–guest complexation between β ‐cyclodextrin and adamantane, was then tested as a drug carrier. Cell viability studies using human ovarian carcinoma cell line (OVCAR‐3) cell lines show a higher toxicity of the shell cross‐linked micelle compared with the free block copolymer.