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Injectable Nanohybrid Scaffold for Biopharmaceuticals Delivery and Soft Tissue Engineering
Author(s) -
Tan Huaping,
Shen Qing,
Jia Xiaojia,
Yuan Zipeng,
Xiong Dangsheng
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200360
Subject(s) - streptavidin , ethylene glycol , scaffold , tissue engineering , hyaluronic acid , nanoparticle , biotin , chemistry , materials science , peg ratio , nanotechnology , biomedical engineering , biochemistry , organic chemistry , anatomy , medicine , finance , economics
An injectable nanofibrous hydrogel scaffold integrated with growth factors (GFs) loaded polysaccharide nanoparticles was developed that specifically allows for targeted adipose‐derived stem cells (ASCs) encapsulation and soft tissue engineering. The nanofibrous hydrogel was produced via biological conjugation of biotin‐terminated star‐shaped poly(ethylene glycol) (PEG‐Biotin) and streptavidin‐functionalized hyaluronic acid (HA‐Streptavidin). The polysaccharide nanoparticles were noncovalently assembled via electrostatic interactions between low‐molecular‐weight heparin (LMWH) and N,N,N ‐trimethylchitosan chloride (TMC). Vascular endothelial growth factor (VEGF) was entrapped in the LMWH/TMC nanoparticles by affinity interactions with LMWH.