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Poly(2‐ethyl‐2‐oxazoline) as Matrix Excipient for Drug Formulation by Hot Melt Extrusion and Injection Molding
Author(s) -
Claeys Bart,
Vervaeck Anouk,
Vervaet Chris,
Remon Jean Paul,
Hoogenboom Richard,
De Geest Bruno G.
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200332
Subject(s) - extrusion , excipient , dissolution , materials science , ethyl cellulose , matrix (chemical analysis) , molding (decorative) , chemical engineering , polymer , polymer chemistry , chromatography , chemistry , organic chemistry , composite material , engineering
Here we evaluate poly(2‐ethyl‐2‐oxazoline)s (PEtOx) as a matrix excipient for the production of oral solid dosage forms by hot melt extrusion (HME) followed by injection molding (IM). Using metoprolol tartrate as a good water‐soluble model drug we demonstrate that drug release can be delayed by HME/IM, with the release rate controlled by the molecular weight of the PEtOx. Using fenofibrate as a lipophilic model drug we demonstrate that relative to the pure drug the dissolution rate is strongly enhanced by formulation in HME/IM tablets. For both drug molecules we find that solid solutions, i.e. molecularly dissolved drug in a polymeric matrix, are obtained by HME/IM.