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Fabricating pH‐Stable and Swellable Very Thin Hyperbranched Poly(ethylene imine)–Oligosaccharide Films Fabricated Without Precoating: First View on Protein Adsorption
Author(s) -
Warenda Monika,
Richter Anne,
Schmidt Diana,
Janke Andreas,
Müller Martin,
Simon Frank,
Zimmermann Ralf,
Eichhorn KlausJochen,
Voit Brigitte,
Appelhans Dietmar
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200255
Subject(s) - materials science , chemical engineering , thin film , copolymer , x ray photoelectron spectroscopy , adsorption , polymer , citric acid , imine , protein adsorption , polymer chemistry , nanotechnology , chemistry , organic chemistry , composite material , catalysis , engineering
For using successful (ultra)thin dendritic macromolecule films in (bio)sensing and microfluidic devices and for obtaining reproducible film properties, alteration effects arising from precoatings have to be avoided. Here, oligosaccharide‐modified hyperbranched poly(ethylene imine)s (PEI‐OS) were used to fabricate very thin PEI‐OS films (15–20 nm in dry state), cross‐linked with citric acid under condensation, and vacuum condition. However, no reactive precoating is necessary to obtain stable films, which allows very simple film preparation and avoids alteration of the PEIS‐OS film properties arising from precoating. Several methods [(in situ) ellipsometry, AFM, XPS, (in situ) ATR‐IR, streaming potential measurements] were applied to characterize homogeneity, surface morphology, and stability of these PEI‐OS films between pH 2 and pH 10, but also the low protein adsorption behavior.