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Functional Monolithic Materials for Boronate‐Affinity Chromatography via Schrock Catalyst‐Triggered Ring‐Opening Metathesis Polymerization
Author(s) -
Bandari Rajendar,
Buchmeiser Michael R.
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200247
Subject(s) - metathesis , polymerization , copolymer , grafting , catalysis , biomolecule , chemistry , polymer chemistry , ring opening metathesis polymerisation , surface modification , hexane , romp , combinatorial chemistry , materials science , organic chemistry , polymer , biochemistry
Monolithic polymeric materials are prepared via ring‐opening metathesis copolymerization of norborn‐2‐ene with 1,4,4a,5,8,8a‐hexahydro‐1,4,5,8‐ exo , endo ‐dimethanonaphthalene in the presence of macro‐ and microporogens, that is, of n ‐hexane and 1,2‐dichloroethane, using the Schrock catalyst Mo(N‐2,6‐(2‐Pr) 2 ‐C 6 H 3 )(CHCMe 2 Ph)(OCMe 3 ) 2 . Functionalization of the monolithic materials is accomplished by either terminating the living metal alkylidenes with various functional aldehydes or by post‐synthesis grafting with norborn‐5‐en‐2‐ylmethyl‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzoate. Finally, boronate‐grafted monolithic columns (100 × 3 mm i.d.) are successfully applied to the affinity chromatographic separation of cis ‐diol‐based biomolecules.