Functional Monolithic Materials for Boronate‐Affinity Chromatography via Schrock Catalyst‐Triggered Ring‐Opening Metathesis Polymerization

Monolithic polymeric materials are prepared via ring‐opening metathesis copolymerization of norborn‐2‐ene with 1,4,4a,5,8,8a‐hexahydro‐1,4,5,8‐ exo , endo ‐dimethanonaphthalene in the presence of macro‐ and microporogens, that is, of n ‐hexane and 1,2‐dichloroethane, using the Schrock catalyst Mo(N‐2,6‐(2‐Pr) 2 ‐C 6 H 3 )(CHCMe 2 Ph)(OCMe 3 ) 2 . Functionalization of the monolithic materials is accomplished by either terminating the living metal alkylidenes with various functional aldehydes or by post‐synthesis grafting with norborn‐5‐en‐2‐ylmethyl‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)benzoate. Finally, boronate‐grafted monolithic columns (100 × 3 mm i.d.) are successfully applied to the affinity chromatographic separation of cis ‐diol‐based biomolecules.