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Hyaluronic Acid/Poly(β‐Amino Ester) Polymer Nanogels for Cancer‐Cell‐Specific NIR Fluorescence Switch
Author(s) -
Park Hye Sun,
Lee Jung Eun,
Cho Mi Young,
Hong Ji Hyeon,
Cho Sang Hee,
Lim Yong Taik
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200246
Subject(s) - nanogel , endosome , endocytosis , hyaluronic acid , chemistry , fluorescence , biophysics , internalization , cancer cell , receptor mediated endocytosis , indocyanine green , polymer , cell , drug delivery , biochemistry , cancer , organic chemistry , biology , medicine , genetics , physics , surgery , quantum mechanics
Abstract Cancer‐cell‐specific pH‐activatable polymer nanogels consisting of CD44‐receptor‐targeting hyaluronic acid (HA), pH‐sensitive poly(β‐amino ester) (PBAE), and near‐infrared (NIR) fluorescent indocyanine green (ICG) were synthesized and used to detect cancer cells. The HA/PBAE/ICG‐polymer‐nanogel‐based NIR probe was nonfluorescent outside of tumor cells. After internalization by CD44‐receptor‐mediated endocytosis, the probe accumulated in the late endosomes or lysosomes where the acidic pH solubilized the PBAE and caused instant disassembly of the polymer nanogel. During endosomal maturation, the encapsulated ICG was released from its quenched state, inducing strong NIR fluorescence recovery. The nanogels generate a highly tumor‐specific NIR signal with a reduced background signal.