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Synthesis and Characterization of PEG‐Based Drug‐Responsive Biohybrid Hydrogels
Author(s) -
Gübeli Raphael J.,
Ehrbar Martin,
Fussenegger Martin,
Friedrich Christian,
Weber Wilfried
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200203
Subject(s) - self healing hydrogels , novobiocin , polyethylene glycol , peg ratio , biocompatible material , nanotechnology , materials science , drug delivery , chemistry , combinatorial chemistry , biomedical engineering , polymer chemistry , organic chemistry , antibiotics , biochemistry , medicine , finance , economics
Interactive materials being responsive to a biocompatible stimulus represent a promising approach for future therapeutic applications. In this study, we present a novel biohybrid material synthesized from biocompatible components being stimulus‐responsive to the pharmaceutically approved small‐molecule novobiocin. The hydrogel design is based on the gyrase B (GyrB) protein, which is covalently grafted to multi‐arm polyethylene glycol (PEG) using a Michael‐type addition reaction. Upon addition of the GyrB‐dimerizing substance coumermycin, stable hydrogels form which can be dissolved in a dose‐adjustable manner by the antibiotic novobiocin. The switchable properties of this PEG‐based hydrogel are favorable for future applications in tissue engineering and as externally controlled drug depot.