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Single Chain Folding of Synthetic Polymers by Covalent and Non‐Covalent Interactions: Current Status and Future Perspectives
Author(s) -
Altintas Ozcan,
BarnerKowollik Christopher
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200049
Subject(s) - covalent bond , folding (dsp implementation) , polymer , chain (unit) , single chain , nanoparticle , hydrogen bond , materials science , nanotechnology , protein folding , non covalent interactions , natural polymers , chemistry , molecule , organic chemistry , physics , biochemistry , astronomy , antibody , electrical engineering , immunology , biology , engineering , composite material
The present feature article highlights the preparation of polymeric nanoparticles and initial attempts towards mimicking the structure of natural biomacromolecules by single chain folding of well‐defined linear polymers through covalent and non‐covalent interactions. Initially, the discussion focuses on the synthesis and characterization of single chain self‐folded structures by non‐covalent interactions. The second part of the article summarizes the folding of single chain polymers by means of covalent interactions into nanoparticle systems. The current state of the art in the field of single chain folding indicates that covalent‐bond‐driven nanoparticle preparation is well advanced, while the first encouraging steps towards building reversible single chain folding systems by the use of mutually orthogonal hydrogen‐bonding motifs have been made.