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Enhanced Selectivity for the Hydrolysis of Block Copoly(2‐oxazoline)s in Ethanol–Water Resulting in Linear Poly(ethylene imine) Copolymers
Author(s) -
van Kuringen Huub P. C.,
de la Rosa Victor R.,
Fijten Martin W. M.,
Heuts Johan P. A.,
Hoogenboom Richard
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201200046
Subject(s) - copolymer , oxazoline , imine , hydrolysis , solvent , polymer chemistry , selectivity , ethylene , materials science , chemistry , organic chemistry , chemical engineering , polymer , catalysis , engineering
The ability of merging the properties of poly(2‐oxazoline)s and poly(ethylene imine) is of high interest for various biomedical applications, including gene delivery, biosensors, and switchable surfaces and nanoparticles. In the present research, a methodology for the controlled and selective hydrolysis of (co)poly(2‐oxazoline)s is developed in an ethanol–water solvent mixture, opening the path toward a wide range of block poly(2‐oxazoline‐ co ‐ethylene imine) (POx‐PEI) copolymers with tunable properties. The unexpected influence of the selected ethanol–water binary solvent mixture on the hydrolysis kinetics and selectivity is highlighted in the pursue of well‐defined POx‐PEI block copolymers.