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Fully‐Branched Hyperbranched Polymers with a Diselenide Core as Glutathione Peroxidase Mimics
Author(s) -
Fu Yu,
Chen Junyi,
Xu Huaping,
Van Oosterwijck Chantal,
Zhang Xi,
Dehaen Wim,
Smet Mario
Publication year - 2012
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/marc.201100860
Subject(s) - moiety , polymer chemistry , diselenide , monomer , chemistry , branching (polymer chemistry) , polymer , nucleophilic substitution , organic chemistry , selenium
A novel glutathione peroxidase (GPx) mimic has been prepared by incorporation of a selenium‐based catalytic unit into the focal point of a fully‐branched hyperbranched polymer. First, an AB 2 monomer consisting of isatin and an electron rich aromatic moiety was polycondensed in the presence of 5‐nitroisatin as a core reagent, resulting in a polymer with 100% degree of branching. The latter was coupled to the catalytically active moiety, Br(CH 2 ) 5 SeSe(CH 2 ) 5 Br, by nucleophilic substitution of the bromides by the residual amide groups of the incorporated nitroisatin core. The obtained polymer has demonstrated prominent GPx activity as desired, which could be attributed to the hydrophobic, densely branched and core‐shell structure of the polymer surrounding the catalytic center.